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  6. Invitrogen™ Ly-49H Monoclonal Antibody (3D10), Biotin, eBioscience™ 

Invitrogen™ Ly-49H Monoclonal Antibody (3D10), Biotin, eBioscience™
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Catalog No. 5011993
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100 μg
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Catalog No. Quantity
50-119-93 100 μg
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Catalog No. 50-119-93 Supplier Invitrogen™ Supplier No. 13588682
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Description

Mouse Monoclonal Antibody

The monoclonal antibody 3D10 recognizes Ly-49H, a member of the C-type lectin Ly-49 multigene family of receptors found on natural killer cells. Ly-49H, like Ly-49D, lacks the characteristic ITIM (immunoreceptor tyrosine-based inhibitory motif) and contains an arginine in the transmembrane domain implying these molecules act as activation receptors. Ly-49H is expressed in a subset of NK cells but not NKT (NK1.1CD3+) cells. Natural killer cells can express several Ly-49 proteins. It has been shown that there is preferential staining of Ly-49H with Ly-49D(Product # 12-5783-81) . Expression has been confirmed on C57BL/6 and NWNA but not Balb/c or DBA/2 mice. Other mice strains have not been tested. No crossreactivity to Ly-49A, C, D or G2 has been observed. Addition of monoclonal antibody 3D10 to cell cultures induces lysis of target cells. Applications Reported:This 3D10 antibody has been reported for use in flow cytometric analysis. Applications Tested: This 3D10 antibody has been tested by flow cytometric analysis of C57Bl/6 spleen cells. This can be used at less than or equal to 1 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Excitation: 633-647 nm; Emission: 660 nm; Laser: Red Laser...

Ly49H is a member of the C-type lectin Ly-49 multigene family of receptors found on natural killer cells. Ly49H, like Ly49D, lacks the characteristic ITAM (immunoreceptor tyrosine-based inhibitory motif) and contains an arginine in the transmembrane domain implying these molecules act as activation receptors. Ly49H is expressed in a subset of NK cells but not NKT (NK1.1/CD3+) cells. Natural killer cells can express several Ly49 proteins.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Ly-49H
Applications Flow Cytometry
Classification Monoclonal
Clone 3D10
Concentration 0.5 mg/mL
Conjugate Biotin
Formulation PBS with 0.09% sodium azide; pH 7.2
Gene Klra8
Gene Accession No. Q60682
Gene Alias Cmv1; Cmv-1; cytomegalovirus resistance 1; killer cell lectin-like receptor 8; killer cell lectin-like receptor, subfamily A, member 8; Klra8; Ly49H; Ly-49h; Ly49-h; Ly49u>129>; Lymphocyte antigen 49h; T-cell surface glycoprotein Ly-49H
Gene Symbols Klra8
Host Species Mouse
Purification Method Affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 16639
Target Species Mouse
Content And Storage 4°C, store in dark, DO NOT FREEZE!
Product Type Antibody
Form Liquid
Isotype IgG1 κ
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