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  6. Invitrogen™ Ly-49H Monoclonal Antibody (3D10), eBioscience™, Invitrogen™ 

Invitrogen™ Ly-49H Monoclonal Antibody (3D10), eBioscience™, Invitrogen™

Catalog No. 14588637
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14-588-637 2 mg
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Catalog No. 14-588-637 Supplier Invitrogen™ Supplier No. 14588637
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Description

Mouse Monoclonal Antibody

The MAb 3D10 recognizes Ly-49H, a member of the C-type lectin Ly-49 multigene family of receptors found on natural killer cells. Ly-49H, like Ly-49D, lacks the characteristic ITIM (immunoreceptor tyrosine-based inhibitory motif) and contains an arginine in the transmembrane domain implying these molecules act as activation receptors. Ly-49H is expressed in a subset of NK cells but not NKT (NK1.1CD3+) cells. Natural killer cells can express several Ly-49 proteins. It has been shown that there is preferential staining of Ly-49H with Ly-49D (cat 12-5783). Expression has been confirmed on C57BL/6 and NWNA but not Balb/c or DBA/2 mice. Other mice strains have not been tested. No crossreactivity to Ly-49A, C, D or G2 has been observed. Addition of MAb 3D10 to cell cultures induces lysis of target cells.

Ly49H is a member of the C-type lectin Ly-49 multigene family of receptors found on natural killer cells. Ly49H, like Ly49D, lacks the characteristic ITAM (immunoreceptor tyrosine-based inhibitory motif) and contains an arginine in the transmembrane domain implying these molecules act as activation receptors. Ly49H is expressed in a subset of NK cells but not NKT (NK1.1/CD3+) cells. Natural killer cells can express several Ly49 proteins.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Ly-49H
Applications Flow Cytometry, Functional Assay, Immunoprecipitation
Classification Monoclonal
Clone 3D10
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.09% sodium azide; pH 7.2
Gene Klra8
Gene Accession No. Q60682
Gene Alias Cmv1; Cmv-1; cytomegalovirus resistance 1; killer cell lectin-like receptor 8; killer cell lectin-like receptor, subfamily A, member 8; Klra8; Ly49H; Ly-49h; Ly49-h; Ly49u>129>; Lymphocyte antigen 49h; T-cell surface glycoprotein Ly-49H
Gene Symbols Klra8
Host Species Mouse
Purification Method Affinity Chromatography
Quantity 2 mg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 16639
Target Species Mouse
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG1 κ
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Safety and Handling

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