Invitrogen™ Lymphotoxin beta Receptor Monoclonal Antibody (eBio3C8 (3C8)), Biotin, eBioscience™, Invitrogen™

Catalog No.	Quantity
50-119-00	100 μg

Catalog No. 50-119-00 Supplier Invitrogen™ Supplier No. 13567182

Description

Rat Monoclonal Antibody

Description: The antibody reacts with mouse lymphotoxin-beta receptor (LTBR). Northern blot analysis of tissues from adult mice showed that expression levels of LTBR mRNA were strong in lung, liver, and kidney, moderate in heart and testes, but weak in brain, thymus, spleen, and lymph nodes. The tumor necrosis factor receptor-related protein is the human receptor for the heterotrimer of lymphotoxin-alpha and lymphotoxin-beta. This LT-alpha/LT-beta heterotrimer (LT-alpha1beta2) is assumed to take part in immunologic reactions by cell-cell contact, but does not bind to either TNFR1 (CD120alpha) or TNFR2 (CD120beta). LTBR is expressed by day 7 embryos, so it has been speculated that the LT-alpha/LT-beta receptor system may also have some function in early embryogenesis. Applications Reported: This eBio3C8 (3C8) antibody has been reported for use in flow cytometric analysis. Applications Tested: This eBio3C8 (3C8) antibody has been tested by flow cytometric analysis of NIH/3T3 cells. This can be used at less than or equal to 0.5 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended to block Fc gamma-receptors with anti-mouse CD16/32 (cat. 14-0161), prior to staining to prevent non-specific binding of eBio3C8.

The protein encoded by this gene is a member of the tumor necrosis factor (TNF) family of receptors. It is expressed on the surface of most cell types, including cells of epithelial and myeloid lineages, but not on T and B lymphocytes. The protein specifically binds the lymphotoxin membrane form (a complex of lymphotoxin-alpha and lymphtoxin-beta). The encoded protein and its ligand play a role in the development and organization of lymphoid tissue and tranformed cells. Activation of the encoded protein can trigger apoptosis.

Specifications

• Antigen: Lymphotoxin beta Receptor
• Applications: Flow Cytometry
• Classification: Monoclonal
• Clone: eBio3C8 (3C8)
• Concentration: 0.5 mg/mL
• Conjugate: Biotin
• Formulation: PBS with 0.09% sodium azide; pH 7.2
• Gene: Ltbr
• Gene Accession No.: P50284
• Gene Alias: AI256028; CD18; D12S370; LT beta-R; Ltar; LT-beta receptor; LTbetaR; LT-BETA-R; Ltbr; lymphotoxin B receptor; lymphotoxin beta receptor; lymphotoxin beta receptor (TNFR superfamily, member 3); lymphotoxin-beta receptor; TNF receptor-related protein; Tnfbr; TNFCR; TNFR2-RP; TNFR3; TNF-RIII; TNF-R-III; TNFR-III; TNFRrp; TNFR-RP; Tnfrsf3; Tumor necrosis factor C receptor; tumor necrosis factor receptor 2-related protein; Tumor necrosis factor receptor superfamily member 3; tumor necrosis factor receptor superfamily, member 3; tumor necrosis factor receptor type III
• Gene Symbols: Ltbr
• Host Species: Rat
• Purification Method: Affinity chromatography
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 17000
• Target Species: Mouse
• Content And Storage: 4°C, store in dark, DO NOT FREEZE!
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1 κ

For Research Use Only.