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  6. Invitrogen™ Lymphotoxin beta Receptor Monoclonal Antibody (eBio3C8 (3C8)), Functional Grade, eBioscience™, Invitrogen™ 

Invitrogen™ Lymphotoxin beta Receptor Monoclonal Antibody (eBio3C8 (3C8)), Functional Grade, eBioscience™, Invitrogen™

Catalog No. 16567138
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16-567-138 5 mg
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Catalog No. 16-567-138 Supplier Invitrogen™ Supplier No. 16567138
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Description

Rat Monoclonal Antibody

The antibody reacts with mouse lymphotoxin-beta receptor (LTBR). Northern blot analysis of tissues from adult mice showed that expression levels of LTBR mRNA were strong in lung, liver, and kidney, moderate in heart and testes, but weak in brain, thymus, spleen, and lymph nodes. The tumor necrosis factor receptor-related protein is the human receptor for the heterotrimer of lymphotoxinalpha and lymphotoxin beta. This LT alpha/LTbeta heterotrimer (LT alpha 1/beta 2) is assumed to take part in immunologic reactions by cell-cell contact, but does not bind to either TNFR1 (CD120 alpha) or TNFR2 (CD120 beta). LTBR is expressed by day 7 embryos, so it has been speculated that the LT alpha/LT beta receptor system may also have some function in early embryogenesis.

The protein encoded by this gene is a member of the tumor necrosis factor (TNF) family of receptors. It is expressed on the surface of most cell types, including cells of epithelial and myeloid lineages, but not on T and B lymphocytes. The protein specifically binds the lymphotoxin membrane form (a complex of lymphotoxin-alpha and lymphtoxin-beta). The encoded protein and its ligand play a role in the development and organization of lymphoid tissue and tranformed cells. Activation of the encoded protein can trigger apoptosis.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Lymphotoxin beta Receptor
Applications Flow Cytometry, Functional Assay
Classification Monoclonal
Clone eBio3C8 (3C8)
Concentration 1 mg/mL
Conjugate Functional Grade
Formulation PBS with no preservative; pH 7.2
Gene Ltbr
Gene Accession No. P50284
Gene Alias AI256028; CD18; D12S370; LT beta-R; Ltar; LT-beta receptor; LTbetaR; LT-BETA-R; Ltbr; lymphotoxin B receptor; lymphotoxin beta receptor; lymphotoxin beta receptor (TNFR superfamily, member 3); lymphotoxin-beta receptor; TNF receptor-related protein; Tnfbr; TNFCR; TNFR2-RP; TNFR3; TNF-RIII; TNF-R-III; TNFR-III; TNFRrp; TNFR-RP; Tnfrsf3; Tumor necrosis factor C receptor; tumor necrosis factor receptor 2-related protein; Tumor necrosis factor receptor superfamily member 3; tumor necrosis factor receptor superfamily, member 3; tumor necrosis factor receptor type III
Gene Symbols Ltbr
Host Species Rat
Purification Method Affinity chromatography
Quantity 5 mg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 17000
Target Species Mouse
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG1 κ
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Safety and Handling

WARNING: Cancer and Reproductive Harm - www.P65Warnings.ca.gov
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