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CPC Scientific Biotin-Lys-Gly-Gly-His-Leu-Lys-Ser-Lys(Me2)-Lys-Gly-Gln-Ser-Thr-Ser-Arg-His-Lys-Lys-Leu-Met-Phe-Lys-Thr-Glu-Gly-Pro-Asp-Ser-Asp-NH2 (trifluoroacetate salt) 1MG
SDP

Supplier:  CPC Scientific CANC012B

Encompass

This is a biotin-labeled and amidated peptide derived from residues 368-393 of human p53 tumor suppressor protein with dimethylation at Lys372 and additional KGW residues on its N-terminus. Methylation at Lys372 activates p53 and induces upregulation of target gene p21. Methylation at Lys372 also inhibits Lys370 methylation by interfering with Smyd2, a lysine methyltransferase, and p53 interaction. Lys 370 methylation reduces p53 transcriptional targets.ONE-LETTER SEQUENCE: Biotin-KGGHLKS-K(Me2)-KGQSTSRHKKLMFKTEGPDSD-NH2MOLECULAR FORMULA: MOLECULAR WEIGHT:3467STORAGE CONDITIONS: -20 5CRESEARCH AREA: CancerREFERENCES: Huang, J. et al. Nature 440, 629 (2006)

Catalog No. 50-210-8887


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