Macro H2A.2 Mouse anti-Human, Clone: OTI1C2, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA526593

Catalog No. PIMA526593

Description

Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in stable X chromosome inactivation.

Specifications

• Antigen: Macro H2A.2
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q9P0M6
• Gene Alias: macroH2A2, core histone macro-H2A.2, core histone macroH2A2.2, histone macroH2A2, mH2A2, H2AFY2
• Host Species: Mouse
• Isotype: IgG2a
• Quantity: 100 μL
• Storage Requirements: -20° C, Avoid Freeze/Thaw Cycles
• Primary or Secondary: Primary
• Gene ID (Entrez): 55506

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Clone: OTI1C2
• Conjugate: Unconjugated
• Gene: H2AFY2
• Format: Liquid
• Gene Symbols: H2AFY2
• Immunogen: Human recombit protein fragment corresponding to amino acids 2-261 of H2AFY2 produced in E.coli
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Type: Antibody
• Monoclonal or Polyclonal: Monoclonal
• Target Species: Human