Invitrogen™ MACROD1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA570915

Catalog No. PIPA570915

Description

This target displays homology in the following species: Cow: 100%; Dog: 92%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rat: 100%.

Removes ADP-ribose from glutamate residues in proteins bearing a single ADP-ribose moiety. Inactive towards proteins bearing poly-ADP-ribose. Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins. Plays a role in estrogen signaling. Binds to androgen receptor (AR) and amplifies the transactivation function of AR in response to androgen. May play an important role in carcinogenesis and/or progression of hormone-dependent cancers by feed-forward mechanism that activates ESR1 transactivation. Could be an ESR1 coactivator, providing a positive feedback regulatory loop for ESR1 signal transduction. Could be involved in invasive growth by down-regulating CDH1 in endometrial cancer cells. Enhances ESR1-mediated transcription activity.

Specifications

• Antigen: MACROD1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: MACROD1
• Gene Alias: [Protein ADP-ribosylaspartate] hydrolase MACROD1; [Protein ADP-ribosylglutamate] hydrolase; [Protein ADP-ribosylglutamate] hydrolase MACROD1; ADP-ribose glycohydrolase MACROD1; ADP-ribose glycohydrolase MACROD1; O-acetyl-ADP-ribose deacetylase MACROD1; AI604841; AW743046; D930010J01Rik; LOC613568 protein; Lrp16; MACRO domain containing 1; MACRO domain-containing protein 1; MACROD1; mono-ADP ribosylhydrolase 1; O-acetyl-ADP-ribose deacetylase MACROD1; O-acetyl-ADP-ribose deacetylase MACROD1; LOW QUALITY PROTEIN: O-acetyl-ADP-ribose deacetylase MACROD1; Protein LRP16
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 28992
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.5 mg/mL
• Formulation: PBS with 2% sucrose and 0.09% sodium azide
• Gene Accession No.: Q9BQ69
• Gene Symbols: MACROD1
• Immunogen: synthetic peptide directed towards the N-terminal region of human MACROD1.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG