MADD Polyclonal Antibody, Bethyl Laboratories

Catalog No.	Quantity
50-157-2419	100 μL
50-157-2420	10 μL

Catalog No. 50-157-2419 Supplier Bethyl Laboratories, Inc Supplier No. IHC00621

Description

Rabbit Polyclonal Antibody

The recommended shelf life for this product is 1 year from date of receipt. Based on 100% sequence identity, this antibody is predicted to react with Mouse, Rat, Bovine, Dog, Horse, Guinea pig_10141, Panda, Orangutan, Monkey, Gorilla and Ch

MAP kinase-activating death domain protein (MADD) was initially identified as the type 1 tumor necrosis factor receptor (TNFR1) associated protein though their death domains. Overexpression of MADD activates MAP kinases ERK and JNK and induces the phosphorylation of cytosolic phospholipase A2. MADD shares 98% identity with DENN (for differentially expressed in neoplastic vs. normal cells), which was recently identified as a substrate for c-jun N-terminal kinase 3 (JNK3). MADD has greater than 94% overall identity to a GDP/GTP exchange protein Rab3-GEP. MADD is 87% identical to KIAA0358, a brain protein of unknown function. Identification of MADD as a component of the TNFR1 signaling complex and the similarity between MADD and Rab3-GEP provides a connection between TNFR1 activation and downstream MAP kinase activity through a guanine-nucleotide exchange protein.

Specifications

• Antigen: MADD
• Applications: Immunofluorescence, Immunohistochemistry
• Classification: Polyclonal
• Conjugate: Unconjugated
• Formulation: TBS with 0.1% BSA and 0.09% sodium azide
• Gene: MADD
• Gene Accession No.: Q8WXG6
• Gene Alias: MAP-Kinase Activating Death Domain, DENN, Differentially Expressed in Neoplasmic vs. Normal Cells
• Gene Symbols: MADD
• Host Species: Rabbit
• Immunogen: Between 1597 and 1647
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 8567
• Target Species: Human
• Content And Storage: 4° C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG