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MAP2 Monoclonal Antibody (AP20), Invitrogen™

Catalog No. PIMA512823
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PIMA512823 500 μL
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Catalog No. PIMA512823 Supplier Thermo Scientific Supplier No. MA512823
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Description

Mouse Monoclonal Antibody

This antibody is specific to MAP2a and MAP2b, and will not cross-react with MAP1, MAP5, tubulin or tau. This clone reacts with dendrites and cell bodies of neurons but not with the neuronal processes. It does not react with the low MW form (70 kDa, MAP2c). The epitope has been mapped to aa 997-1332. The molecular weight of the doublet is ∽280 kDa. For IHC staining, formalin-fixed tissues must be boiled in a 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at room temperature for 20 min. Recommened positive controls include human glioblastoma T98G cells or brain tissue.

MAP2 (Microtubule Associated Protein 2) exists in two high molecular weight forms (MAP2a & MAP2b) and a low molecular weight form. The expression of MAP2 is developmentally regulated and its multiple forms arise by alternative splicing of a single gene. MAP2 is involved in microtubule assembly, which is an essential step in neurogenesis. The products of similar genes in rat and mouse are neuron-specific cytoskeletal proteins that are enriched in dendrites, implicating a role in determining and stabilizing dendritic shape during neuron development. MAP2 is useful in studies of neuron structure in normal and malignant brain tissue as well as in degenerative diseases such as Alzheimer's Disease (AD).
TRUSTED_SUSTAINABILITY

Specifications

Antigen MAP2
Applications Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone AP20
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation tissue culture supernatant with 0.09% sodium azide
Gene Map2
Gene Accession No. P11137
Gene Alias a730034c02; AC091465.1; DKFZp686I2148; G1-397-34; MAP 2; Map2; MAP-2; map2.S; map2a; map-2a; map2ab; MAP2B; MAP2C; MAP2R; microtubule associated protein 2; microtubule associated protein 2 S homeolog; microtubule associated protein 2; microtubule-associated protein 2; microtubule associated protein 2C; microtubule-associated protein 2; microtubule-associated protein-2; Mtap2; Mtap-2; OTTHUMP00000163916; OTTHUMP00000208143; repro4; XELAEV_18047318mg; xmap2
Gene Symbols Map2
Host Species Mouse
Immunogen Bovine brain microtubule associated protein 2
Quantity 500 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 281294, 4133
Target Species Bovine, Human
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype IgG1
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