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Invitrogen™ MAP2 Monoclonal Antibody (M13)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ 131500

Encompass_Preferred

Catalog No. 13-150-0


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Description

Description

This antibody reacts with a 300 kD cytoskeletal protein (MAP2A and MAP2B) primarily expressed in the somatodendritic domain of the neuron but is also found in the glia. Reactivity is not affected by phospohorylation state of MAP2. Abnormal expression of MAP2 may cause cytoskeletal abnormalities and impair signal transduction in dendrites. This antibody is suitable for immunohistochemical staining of alcohol-fixed paraffin embedded or frozen tissue sections.

MAP2 (Microtubule Associated Protein 2) exists in two high molecular weight forms (MAP2a & MAP2b) and a low molecular weight form. The expression of MAP2 is developmentally regulated and its multiple forms arise by alternative splicing of a single gene. MAP2 is involved in microtubule assembly, which is an essential step in neurogenesis. The products of similar genes in rat and mouse are neuron-specific cytoskeletal proteins that are enriched in dendrites, implicating a role in determining and stabilizing dendritic shape during neuron development. MAP2 is useful in studies of neuron structure in normal and malignant brain tissue as well as in degenerative diseases such as Alzheimer's Disease (AD).
TRUSTED_SUSTAINABILITY
Specifications

Specifications

MAP2
Monoclonal
0.5 mg/mL
PBS with 0.1% sodium azide; pH 7.4
P11137, P15146, P20357
Map2
MAPs.
100 μg
Primary
Human, Mouse, Rat
Antibody
IgG1 κ
ELISA, Immunohistochemistry, Immunoprecipitation, Western Blot, Immunocytochemistry
M13
Unconjugated
Map2
a730034c02; AC091465.1; DKFZp686I2148; G1-397-34; MAP 2; Map2; MAP-2; map2.S; map2a; map-2a; map2ab; MAP2B; MAP2C; MAP2R; microtubule associated protein 2; microtubule associated protein 2 S homeolog; microtubule associated protein 2; microtubule-associated protein 2; microtubule associated protein 2C; microtubule-associated protein 2; microtubule-associated protein-2; Mtap2; Mtap-2; OTTHUMP00000163916; OTTHUMP00000208143; repro4; XELAEV_18047318mg; xmap2
Mouse
Purified
RUO
17756, 25595, 4133
-20°C
Liquid
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