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MAP3K5 Rabbit anti-Human, Mouse, Polyclonal, liquid, OriGene
SDP

Catalog No. 501684734
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50-168-4734 100 μL
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Catalog No. 50-168-4734 Supplier OriGene Supplier No. TA890021
May include imposed supplier surcharges.
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Description

Rabbit Polyclonal Antibody

Mitogen-activated protein (MAP) kinase cascades are activated in response to various extracellular stimuli, including cytokines, growth factors and environmental stresses. A novel MAP kinase kinase kinase (MAPKKK) was identified and designated ASK1 (for apoptosis signal-regulating kinase 1) and MAPKKK5. ASK1 activates two different subgroups of MAPKK, MKK4 and MKK6, which in turn activates c-Jun N-terminal kinase (JNK) and p38 MAP kinase, respectively. ASK1/MAPKKK5 is activated by TNFR and Fas through the interaction with members of the TRAF family and Fas-associated protein Daxx. Overexpression of ASK1 induced apoptotic cell death and a catalytically inactive form of ASK1 inhibited TNF-a-induced apoptosis. ASK1 is expressed in variety of human and mouse tissues.

Specifications

Antigen MAP3K5
Applications Western Blot
Classification Polyclonal
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide
Gene MAP3K5
Gene Accession No. O35099, Q99683
Gene Alias ASK1, MAPKKK5, MEKK5
Gene Symbols Map3k5
Host Species Rabbit
Immunogen Recombit protein of human MAP3K5
Purification Method Antigen Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 26408, 4217
Target Species Human, Mouse
Content And Storage -20° C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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