Invitrogen™ Human MAP3K7/MAP3K7IP1 (TAK1-TAB1), His Tag Recombinant Protein

Catalog No.	Quantity
PV4394	10 μg

Catalog No. PV4394 Supplier Invitrogen™ Supplier No. PV4394

Description

Recombinant Protein

For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 μg, 10 μg and 20 μg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 μL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase. Protein Form: Full Length.

MAP3K7 (TAK1) controls transcription regulation and apoptosis, and is implicated in inflammatory disease and rheumatoid arthritis. Fusion of MAP3K7 to MAP3K7IP1 (TAB1) activates MAP3K7. Originally identified as a TGF- beta-activated kinase, TAK1 interacts with TGF- beta-receptor and TRAF6 to modulate TGF- beta activation of JNK and p38. It has additional roles in activation of p38 and JNK through Wnt, BMP, and activin signaling pathways as well in response to thyroid hormone, osmotic stress, endothelin, and ephrine. TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 (TAB1) is a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. TAB1 interacts and thus activates TAK1 kinase.

Specifications

• Accession Number: O43318, Q15750
• Concentration: See Label
• For Use With (Application): Kinase Assay
• Formulation: 50mM tris with 150mM NaCl, 0.02% Triton X-100, 50% glycerol, 2mM DTT, 0.5mM EDTA and no preservative; pH 7.5
• Gene ID (Entrez): 10454, 6885
• Molecular Weight (g/mol): 45.8 kDa
• Name: Human MAP3K7/MAP3K7IP1 (TAK1-TAB1), His Tag
• pH Range: 7.5
• Purification Method: Purified
• Quantity: 10 μg
• Storage Requirements: -80°C, Avoid Freeze/Thaw Cycles
• Regulatory Status: RUO
• Gene Alias: TAB1; TAK1
• Common Name: TAK1/TAB1
• Gene Symbol: MAP3K7, TAB1
• KinaseFamily: MLK Kinase Family
• Protein Length: 1-596
• Product Type: Protein
• Conjugate: Unconjugated
• Species: Human
• Recombinant: Recombinant
• Protein Tag: His-tag
• Sequence: 1-596
• Content And Storage: -80°C, Avoid Freeze/Thaw Cycles
• Assay Entry: Biochemical terbium phospho-specific activity, Biochemical binding/kinetic
• Kinase Group: Ser⁄Thr Kinases: TKL Group
• Shipping Condition: Dry Ice
• System Compatibility: LanthaScreen™ Antibody, LanthaScreen™ Substrate
• Target Entry: MAP3K7/MAP3K7IP1
• Target Gene: mitogen-activated protein kinase kinase kinase 7
• Expression System: Insect cells
• Protein Family: Kinases & Inhibitors
• Protein Form: Recombinant, Full Length
• Form: Liquid
• Protein Subtype: Serine/Threonine Kinases
• Research Category: Signal Transduction
• Purity or Quality Grade: 55% by SDS-PAGE