MAP3K8 Monoclonal Antibody (OTI3D9), TrueMAB™, OriGene

Mouse Monoclonal Antibody

Supplier:  OriGene TA808390

Catalog No. 50-168-2097

Description

Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MEKK8 is able to activate NF-kappa-B 1 by stimulating proteasome-mediated proteolysis of NF-kappa-B 1/p105. The protein appears to play an important role in the cell cycle. This cytoplasmic protein is expressed in several normal tissues and human tumor-derived cell lines. The 58 kDa form is activated specifically during the S and G2/M phases of the cell cycle. The longer form undergoes phosphorylation on Ser residues mainly, and the shorter form on both Ser and Thr residues.

Specifications

• Antigen: MAP3K8
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene Accession No.: P41279
• Gene Symbols: MAP3K8
• Immunogen: Human recombit protein fragment corresponding to amino acids 277-461 of human MAP3K8 produced in E.coli.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: Western Blot
• Clone: OTI3D9
• Conjugate: Unconjugated
• Gene: MAP3K8
• Gene Alias: AURA2, COT, EST, ESTF, MEKK8, TPL2, Tpl-2, c-COT
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 1326
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid