Invitrogen™ MARCH1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA553199

Catalog No. PIPA553199

Description

Immunogen sequence: KVYVQLWRRL KAYNRVIFVQ NCPDTAKKLE KNFSCNVNTD IKDAVVVPVP QTGANSLPSA EGG Highest antigen sequence identity to the following orthologs: Mouse - 89%, Rat - 87%.

E3 ubiquitin-protein ligase that mediates ubiquitination of TFRC, CD86, FAS and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. By constitutively ubiquitinating MHC class II proteins in immature dendritic cells, down-regulates their cell surface localization thus sequestering them in the intracellular endosomal system.

Specifications

• Antigen: MARCH1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: MARCH1
• Gene Alias: 1-Mar; 2900024D24Rik; BB085186; E3 ubiquitin-protein ligase MARCH1; MARCH1; MARCHF1; MARCH-I; membrane associated ring finger 1; membrane associated ring-CH-type finger 1; membrane-associated ring finger (C3HC4) 1; membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase; membrane-associated RING finger protein 1; Membrane-associated RING-CH protein I; RGD1305148; RING finger protein 171; RING-type E3 ubiquitin transferase MARCH1; RNF171
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 55016
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q8TCQ1
• Gene Symbols: MARCH1
• Immunogen: Recombinant protein corresponding to Human MARCH1. Recombinant protein control fragment (Product #RP-90986).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG