MASP2 Monoclonal Antibody (c5), Invitrogen™

Mouse Monoclonal Antibody

Catalog Number	Mfr. No.	Quantity
PIMA543666	Invitrogen™ MA543666	20 μL
PIMA543665	Invitrogen™ MA543665	100 μL

Description

Mannose (or mannan)-binding lectin (MBL), also known as serum mannosebinding protein (MBP), initiates the lectin branch of the innate immune response by binding to the surface of potentially pathogenic microorganisms and initiating complement fixation through an N-terminal collagen-like domain. MBL is a key component in immune response in that it can directly trigger neutralization of invading microorganisms by an Ab-independent mechanism. Mutations of human MBL are associated with immunodeficiency resulting from a reduction in the ability of the mutant MBL to initiate complement fixation. In human, three types of MBL-associated serine proteases, MASP-1, MASP-2 and MASP-3, and a truncated form of MASP-2 (small MBL-associated protein; sMAP or MAp19) complex with MBL to activate the lectin pathway of the complement system. Activated MASPs subsequently cleave and activate downstream components of the complement pathway. MASP-3 is an alternatively spliced product from the MASP-1 gene and may function to inhibit MASP-2 by competing for MBL binding and inhibiting the activation of MBLassociated MASP-2.

Specifications

• Antigen: MASP2
• Concentration: 1 mg/mL
• Classification: Monoclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.05% ProClin 300
• Gene Alias: mannan binding lectin serine peptidase 2; mannan-binding; mannan-binding lectin serine peptidase 1 pseudogene 1; mannan-binding lectin serine peptidase 2; mannan-binding lectin serine peptidase 2 variant 1; mannan-binding lectin serine peptidase 2 variant 2; mannan-binding lectin serine peptidase 2 variant 3; mannan-binding lectin serine peptidase 2 variant 4; mannan-binding lectin serine protease 1 pseudogene 1; mannan-binding lectin serine protease 2; Mannan-binding lectin serine protease 2 A chain; Mannan-binding lectin serine protease 2 B chain; mannose binding lectin-associated serine protease-2; mannose-binding protein-associated serine protease 2; MAp19; MASP1P1; Masp2; MASP-2; MBL-associated plasma protein of 19 kD; MBL-associated serine protease 2; sb:eu714; small MBL-associated protein; sMAP; wu:fb62a09
• Gene Symbols: MASP2
• Isotype: IgG2b κ
• Purification Method: Protein A/G
• Product Type: Antibody

• Clone: C9
• Applications: Western Blot
• Conjugate: Unconjugated
• Host Species: Mouse
• Target Species: Human
• Gene Accession No.: O00187
• Gene ID (Entrez): 10747
• Immunogen: Gly170-Thr287 (Accession O00187), with N-terminal His Tag.
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: MASP2