MAST2 Monoclonal Antibody (OTI3A5), TrueMAB™, OriGene

Catalog No.	Quantity
50-168-2372	100 μL

Catalog No. 50-168-2372 Supplier OriGene Supplier No. TA808790

Description

Mouse Monoclonal Antibody

Syntrophin is an adapter protein that functions to bind certain signaling molecules to the dystrophin-associated protein complex. This complex connects the extracellular matrix to the intracellular cytoskeleton for construction and maintece of the postsynaptic structures in the neuromuscular junction and the central nervous system. Microtubule-associated serine/threonine-protein kinase 2 (MAST205) is a testis-specific, cytoplasmic protein that functions in a multi-protein complex in the maturation of spermatids. MAST205 is involved in linking the dystrophin/utrophin network with microtubule filaments via Syntrophin. By forming a complex with TRAF6, MAST205 regulates lipopolysaccharide-induced IL-12 synthesis in macrophages. This leads to the inhibition of TRAF6 NF-kappa-B activation. Two isoforms exist for MAST205 due to alternative splicing. Isoform 1 represents the full length protein, while isoform 2 lacks the residues 327-396 and 1091-1113. The N-terminus of MAST205 must be phosphorylated in order for ubiquitination to occur at the same site. This ubiquitination leads to the degradation of MAST205 via proteasome-mediated proteolysis.

Specifications

• Antigen: MAST2
• Applications: Western Blot
• Classification: Monoclonal
• Clone: OTI3A5
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene: MAST2
• Gene Accession No.: Q6P0Q8
• Gene Alias: MAST205, MTSSK
• Gene Symbols: MAST2
• Host Species: Mouse
• Immunogen: Human recombit protein fragment corresponding to amino acids 1482-1798 of human MAST2 produced in E.coli.
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 23139
• Target Species: Human
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1