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MAVS/VISA Rabbit anti-Human, Polyclonal, Bethyl Laboratories

Catalog No. 501558435
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50-155-8435 10 μL
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Catalog No. 50-155-8435 Supplier Bethyl Laboratories, Inc Supplier No. A300783AT
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Description

Rabbit Polyclonal Antibody

The recommended shelf life for this product is 1 year from date of receipt.

Two distinct signaling pathways activate the host innate immunity against viral infection. One pathway is reliant on members of the Toll-like receptor (TLR) family while the other uses the RNA helicase RIG-I as a receptor for intracellular viral double-stranded RNA as a trigger for the immune response. VISA is a mitochondrial membrane protein that was identified as a critical component in the IFN-b signaling pathways that recruits IRF-3 to RIG-I, leading to its activation and that of NF-kappa-B. VISA is also thought to interact with other components of the innate immune pathway such as the TLR adapter protein TRIF, TRAF2 and TRAF6. VISA also interacts with the IKK-a, IKK-b and IKK-iota kinases through its C-terminal region. Cleavage of this region by the Hepatitis C virus (HCV) protease allows HCV to escape the host immune system. At least three isoforms of VISA are known to exist.

Specifications

Antigen MAVS/VISA
Applications Immunoprecipitation
Classification Polyclonal
Concentration 1 mg/ml
Conjugate Unconjugated
Formulation phosphate, tris citrate with 0.09% sodium azide; pH 7-8
Gene MAVS
Gene Accession No. Q7Z434
Gene Alias CARD adapter inducing interferon beta; CARD adapter inducing interferon-beta; CARD adaptor inducing IFN-beta; IFN-B promoter stimulator 1; interferon beta promoter stimulator protein 1; interferon-beta promoter stimulator protein 1; mitochondrial anti-viral signaling protein; mitochondrial antiviral-signaling protein; putative NF-kappa-B-activating protein 031N; virus-induced signaling adapter variant 1b; virus-induced signaling adaptor variant 1a; virus-induced-signaling adapter
Gene Symbols MAVS
Host Species Rabbit
Immunogen Between 250 and 300
Purification Method Antigen affinity chromatography
Quantity 10 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 57506
Target Species Human
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype IgG
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