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Invitrogen™ MBD1 Monoclonal Antibody (100B272.1)
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Catalog No. 01676441
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Quantity:
100 μg
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Catalog No. Quantity
01-676-441 100 μg
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Catalog No. 01-676-441 Supplier Invitrogen™ Supplier No. MA141025
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Description

Mouse Monoclonal Antibody

Suggested positive control: Hela whole cell extract, HeLa cell lysate. Immunogen sequence: SESEDGAGSP PPYRR.

Methyl-CpG-binding domain protein 1 (MBD1) is a member of a family of mammalian proteins that specifically bind methylated regions of DNA. It is a transcriptional repressor that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binding is abolished by the presence of 7-mG that is produced by DNA damage by methylmethanesulfonate (MMS). MBD1 acts as a transcriptional repressor and plays a role in gene silencing by recruiting AFT7IP, which in turn recruits factors such as the histone methyltransferase SETDB1. Isoform 1 and isoform 2 can also repress transcription from unmethylated promoters.
TRUSTED_SUSTAINABILITY

Specifications

Antigen MBD1
Applications ChIP Assay, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Monoclonal
Clone 100B272.1
Concentration 1.0 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene MBD1
Gene Accession No. Q9UIS9, Q9Z2E2
Gene Alias CXXC3; CXXC-type zinc finger protein 3; Mbd1; methyl-CpG binding domain protein 1; methyl-CpG binding domain protein 1 isoform PCM1; methyl-CpG-binding domain protein 1; Methyl-CpG-binding protein MBD1; PCM1; Protein containing methyl-CpG-binding domain 1; RFT; the regulator of fibroblast growth factor 2 (FGF-2) transcription
Gene Symbols MBD1
Host Species Mouse
Immunogen Synthetic peptide corresponding to amino acids 391-405 of human MBD1.
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 17190, 4152
Target Species Human, Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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