Invitrogen™ MBD1 Polyclonal Antibody

Catalog No.	Quantity
01-675-523	100 μg

Catalog No. 01-675-523 Supplier Invitrogen™ Supplier No. PA141394

Description

Rabbit Polyclonal Antibody

Suggested positive control: Hela whole cell extract, HeLa cell lysate. Immunogen sequence: RQVGPQSGEV RKEAPR & SESEDGAGSP PPYRR.

Methyl-CpG-binding domain protein 1 (MBD1) is a member of a family of mammalian proteins that specifically bind methylated regions of DNA. It is a transcriptional repressor that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binding is abolished by the presence of 7-mG that is produced by DNA damage by methylmethanesulfonate (MMS). MBD1 acts as a transcriptional repressor and plays a role in gene silencing by recruiting AFT7IP, which in turn recruits factors such as the histone methyltransferase SETDB1. Isoform 1 and isoform 2 can also repress transcription from unmethylated promoters.

Specifications

• Antigen: MBD1
• Applications: Western Blot
• Classification: Polyclonal
• Concentration: 0.5 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 0.02% sodium azide
• Gene: MBD1
• Gene Accession No.: Q9UIS9
• Gene Alias: CXXC3; CXXC-type zinc finger protein 3; Mbd1; methyl-CpG binding domain protein 1; methyl-CpG binding domain protein 1 isoform PCM1; methyl-CpG-binding domain protein 1; Methyl-CpG-binding protein MBD1; PCM1; Protein containing methyl-CpG-binding domain 1; RFT; the regulator of fibroblast growth factor 2 (FGF-2) transcription
• Gene Symbols: MBD1
• Host Species: Rabbit
• Immunogen: Mixture of synthetic peptides corresponding to amino acids 98-113 and 391-405 of human MBD1.
• Purification Method: Protein G
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 4152
• Target Species: Human
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG