MBD2 Rabbit anti-Human, Rat, Polyclonal, Proteintech

Catalog No.	Quantity
50-173-6052	150 μL

Catalog No. 50-173-6052 Supplier Proteintech Group Inc Supplier No. 552001AP150UL

Description

Rabbit Polyclonal Antibody

This antibody is specific to MBD2. It recognize isoform1 and isoform2 of MBD2.

Heterochromatin protein-1 (HP1) is a methyl-lysine binding protein localized at heterochromatin sites, where it mediates gene silencing. It has been shown that mammalian methyltransferases that selectively methylate histone H3 on lysine-9 generate a binding site for HP1 proteins, a family of heterochromatic adaptor molecules implicated in both gene silencing and supranucleosomal chromatin structure. High-affinity in vitro recognition of a methylated histone H3 peptide by HP1 requires a functional chromodomain. Thus, the HP1 chromodomain is a specific interaction motif for the methyl epitope on lysine-9 of histone H3. In vivo, heterochromatin association of HP1 proteins is lost in Suv39h double-null primary mouse fibroblasts but is restored after reintroduction of a catalytically active SUV39H1 HMTase.

Specifications

• Antigen: MBD2
• Applications: Western Blot
• Classification: Polyclonal
• Concentration: 0.28 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene: MBD2
• Gene Accession No.: Q9UBB5
• Gene Alias: Demethylase, DMTase, MBD2, NY CO 41
• Gene Symbols: MBD2
• Host Species: Rabbit
• Immunogen: Peptide
• Purification Method: Antigen Affinity Chromatography
• Quantity: 150 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 680172, 8932
• Target Species: Human, Rat
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG