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Invitrogen™ MBD2 Recombinant Rabbit Monoclonal Antibody (24GB460)
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Catalog No. MA557472
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MA557472 100 μL
MA557473 20 μL
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Catalog No. MA557472 Supplier Invitrogen™ Supplier No. MA557472
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Description

Rabbit Recombinant Monoclonal Antibody

MBD2 Recombinant Monoclonal Antibody for Flow, ICC/IF, Western Blot

Heterochromatin protein-1 (HP1) is a methyl-lysine binding protein localized at heterochromatin sites, where it mediates gene silencing. It has been shown that mammalian methyltransferases that selectively methylate histone H3 on lysine-9 generate a binding site for HP1 proteins, a family of heterochromatic adaptor molecules implicated in both gene silencing and supranucleosomal chromatin structure. High-affinity in vitro recognition of a methylated histone H3 peptide by HP1 requires a functional chromodomain. Thus, the HP1 chromodomain is a specific interaction motif for the methyl epitope on lysine-9 of histone H3. In vivo, heterochromatin association of HP1 proteins is lost in Suv39h double-null primary mouse fibroblasts but is restored after reintroduction of a catalytically active SUV39H1 HMTase.
TRUSTED_SUSTAINABILITY

Specifications

Antigen MBD2
Applications Flow Cytometry, Western Blot, Immunocytochemistry
Classification Recombinant Monoclonal
Clone 24GB460
Concentration 1.05 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Mbd2
Gene Accession No. Q9UBB5, Q9Z2E1
Gene Alias demethylase; DKFZp586O0821; DMTase; MBD2; MBD2a; methyl-CpG binding domain protein 2; methyl-CpG-binding domain protein 2; Methyl-CpG-binding protein MBD2; NY-CO-41
Gene Symbols Mbd2
Host Species Rabbit
Immunogen A synthesized peptide derived from human MBD2 (aa 100-165).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 17191, 680172, 8932
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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