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Invitrogen™ MC4R Polyclonal Antibody
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Catalog No. PIPA520759 Shop All Thermo Scientific Products
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PIPA520759 100 μg
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Catalog No. PIPA520759 Supplier Invitrogen™ Supplier No. PA520759
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Description

Rabbit Polyclonal Antibody

A suggested positive control is rat brain tissue lysate. PA5-20759 can be used with blocking peptide PEP-0873.

Expression of MC4R has been reported in brain. Unlike the other melanocortin receptors, MC4R is not expressed in adrenal cortex or in melanocytes. G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms. An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors. Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs. This turn-off activity has tremendous implications for the physiological action of the cell, and continues to drive pharmacological research for new drug candidates. Two blockbuster drugs which have been developed as GPCR-targeted pharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough) which have multi-billion dollar shares of the mental health and allergy markets, respectively.
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Specifications

Antigen MC4R
Applications Immunohistochemistry, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene MC4R
Gene Accession No. P32245, P56450, P70596
Gene Alias MC4; MC4 receptor; mc4r; Mc4-r; melanocortin 4 receptor; melanocortin receptor 4; si:dkey-151m6.62; zMC4
Gene Symbols MC4R
Host Species Rabbit
Immunogen A 19 amino acid peptide near the amino terminus of human MC4R.
Purification Method Antigen Affinity Chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 17202, 25635, 4160
Target Species Human, Mouse, Rat
Content And Storage Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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