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Invitrogen™ MCM4 Polyclonal Antibody
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Catalog No. PIPA565088
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PIPA565088 100 μL
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Catalog No. PIPA565088 Supplier Invitrogen™ Supplier No. PA565088
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: SSPPQMHSSAI PLDFDVSSPL TYGTPSSRVE GTPRSGVRGT PVRQRPDLGS AQKGLQVDLQ SDGAAAEDIV ASEQSLGQKL VIWGTDVNVA ACKENFQRFL QRFIDPLAKE EENVG Highest antigen sequence identity to the following orthologs - mouse 95%, rat 93%.

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported.
TRUSTED_SUSTAINABILITY

Specifications

Antigen MCM4
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Mcm4
Gene Accession No. P33991
Gene Alias 19G; AI325074; AU045576; cb1025; Cdc21; CDC21 homolog; CDC54; DNA replication licensing factor MCM4; fc12c09; fj85g09; hCdc21; hm:zeh1616; homolog of S. pombe cell devision cycle 21; mcdc21; MCM4; MCM4 minichromosome maintenance deficient 4; MCM4 minichromosome maintenance deficient 4, mitotin; mcm4 protein; Mcmd4; mini chromosome maintenance deficient 4 homolog; minichromosome maintenance complex component 4; minichromosome maintenance deficient 4; minichromosome maintenance deficient 4 homolog; minichromosome maintenance deficient 4 homolog (S. cerevisiae); mKIAA4003; NKCD; NKGCD; P1-CDC21; Unknown (protein for MGC:140484); wu:fc12c09; wu:fj85g09; zeh1616
Gene Symbols Mcm4
Host Species Rabbit
Immunogen Recombinant Human MCM4. Recombinant protein control fragment (Product #RP-104624).
Purification Method Antigen Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 4173
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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