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Invitrogen™ MCU Monoclonal Antibody (CL3576)
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Catalog No. PIMA524702
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100 μL
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PIMA524702 100 μL
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Catalog No. PIMA524702 Supplier Invitrogen™ Supplier No. MA524702
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Description

Mouse Monoclonal Antibody

Immunogen sequence: TRQEYVYPEAR DRQYLLFFHK GAKKSRFDLE KYNQLKDAIA QAEMDLKRLR DPLQVHLPLR QIGE Binds to an epitope located within the peptide sequence RDRQYLLFFH as determined by overlapping synthetic peptides. Highest antigen sequence identity to the following orthologs - mouse 100%, rat 100%.

Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Constitutes the pore-forming and calcium-conducting subunit of the uniporter complex (uniplex). Activity is regulated by MICU1 and MICU2. At low Ca(2+) levels MCU activity is down-regulated by MICU1 and MICU2; at higher Ca(2+) levels MICU1 increases MCU activity. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. Involved in buffering the amplitude of systolic calcium rises in cardiomyocytes. While dispensable for baseline homeostatic cardiac function, acts as a key regulator of short-term mitochondrial calcium loading underlying a 'fight-or-flight' response during acute stress: acts by mediating a rapid increase of mitochondrial calcium in pacemaker cells. participates in mitochondrial permeability transition during ischemia-reperfusion injury. Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake. Mitochondrial calcium uptake in skeletal muscle cells is involved in muscle size in adults. Regulates synaptic vesicle endocytosis kinetics in central nerve terminal. Involved in antigen processing and presentation.
TRUSTED_SUSTAINABILITY

Specifications

Antigen MCU
Applications Western Blot, Immunocytochemistry
Classification Monoclonal
Clone CL3576
Concentration 1.00 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene MCU
Gene Accession No. Q8NE86
Gene Alias 2010012O16Rik; AV064928; C10orf42; Calcium uniporter protein, mitochondrial; Ccdc109a; coiled-coil domain containing 109A; coiled-coil domain-containing protein 109A; D130073L02Rik; Gm64; HsMCU; MCU; mitochondrial calcium uniporter
Gene Symbols MCU
Host Species Mouse
Immunogen Recombinant protein fragment of Human MCU (Product #RP-108152)
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 90550
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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