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Enzo Life Sciences Mdivi-1 (50mg). CAS: 338967-87-6
SDP

Supplier:  Enzo Life Sciences BMLCM1270050

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Mdivi-1 is a selective inhibitor of mitochondrial division in yeast and mammalian cells which acts via inhibiting the mitochondrial division dynamin. In cells, Mdivi-1 inhibits apoptosis by inhibiting mitochondrial outer membrane permeabilization. Mdivi-1 causes the rapid (<5 min) reversible and dose-dependent formation of net-like mitochondria in wild-type cells with an IC50= ~10µM. In yeast, time-lapse fluorescence microscopy revealed no detectable mitochondrial division after treatment with Mdivi-1. It inhibits Dnm1 GTPase activity in a dose dependent manner with an estimated IC50 of 1-10µM but is not a general inhibitor of GTPases. Purity: ≥97% (HPLC). Solubility: Soluble in DMSO (25mg/ml). Long Term Storage: -20°C.

Catalog No. 50-201-0434


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