Meclizine dihydrochloride monohydrate, Thermo Scientific™

Description

Antiemetic and H1-histamine receptor antagonist

This Thermo Scientific brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific.

Applications
Antiemetic and H1-histamine receptor antagonistMeclizine dihydrochloride monohydrate acts as an antiemetic. It is also used for the prevention and treatment of nausea during pregnancy. In addition to this, it is used in radiation sickness, vomiting or dizziness associated with motion sickness.

Solubility
Insoluble in water.

Notes
Incompatible with heat and oxidizing agents.

Specifications

Chemical Identifiers

• CAS: 31884-77-2
• Molecular Formula: C25H31Cl3N2O
• Molecular Weight (g/mol): 481.886
• MDL Number: MFCD00058199
• InChI Key: KDLHYOMCWBWLMM-UHFFFAOYSA-N
• Synonym: meclizine hydrochloride, meclizine dihydrochloride monohydrate, meclizine hcl, antivert tn, c25h27cln2.2hcl.h2o, 1-p-chloro-alpha-phenylbenzyl-4-m-methylbenzyl piperazine dihydrochloride monohydrate, 1-4-chlorophenyl-phenylmethyl-4-3-methylphenyl methyl piperazine hydrate dihydrochloride, piperazine, 1-4-chlorophenyl phenylmethyl-4-3-methylphenyl methyl-, dihydrochloride, monohydrate, meclizine hcl hydrate, meclizine hydrochloride usan:jan
• PubChem CID: 173612
• IUPAC Name: 1-[(4-chlorophenyl)-phenylmethyl]-4-[(3-methylphenyl)methyl]piperazine;hydrate;dihydrochloride
• SMILES: CC1=CC(=CC=C1)CN2CCN(CC2)C(C3=CC=CC=C3)C4=CC=C(C=C4)Cl.O.Cl.Cl

• Melting Point: 210°C to 213°C
• Color: White
• Quantity: 1 g
• Merck Index: 14,5777
• Solubility Information: Insoluble in water.
• Formula Weight: 481.89 (463.88 Anhydrous)
• Physical Form: Powder
• Chemical Name or Material: Meclizine dihydrochloride monohydrate

Safety and Handling

Hazard Category	H302-H361
Hazard Statement	GHS H Statement H361-H302 Suspected of damaging fertility or the unborn child. Harmful if swallowed.
Precautionary Statement	P201-P202-P264b-P270-P281-P301+P312-P308+P313-P330-P501c
TSCA	Yes
Recommended Storage	Store at -20°C

SDS