Invitrogen™ MECP2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA141006

Catalog No. 01-676-628

Description

Suggested positive control: Hela whole cell extract, HeLa cell lysate.

MECP2 belongs to a family of nuclear proteins (including MBD1, MBD2, MBD3 and MBD4) that have a methyl-CpG binding domain. MECP2 is capable of binding specifically to methylated DNA. DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. MECP2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females.

Specifications

• Antigen: MECP2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Mecp2
• Gene Alias: 1500041B07Rik; AUTSX3; D630021H01Rik; DKFZp686A24160; Mbd5; MECP2; MeCp-2 protein; methyl CpG binding protein 2; methyl-CpG binding protein 2; methyl-CpG-binding protein 2; MRX16; MRX79; MRXS13; MRXSL; PPMX; RS; RTS; RTT; testis tissue sperm-binding protein Li 41a; WBP10
• Host Species: Rabbit
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 17257, 4204
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.5 mg/mL
• Formulation: PBS with 0.2% gelatin and 0.05% sodium azide
• Gene Accession No.: P51608, Q9Z2D6
• Gene Symbols: Mecp2
• Immunogen: Synthetic peptides corresponding to residues 11-25 and 181-195 of human MeCP2.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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