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Invitrogen™ MECP2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA141006

Catalog No. 01-676-628


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Description

Description

Suggested positive control: Hela whole cell extract, HeLa cell lysate.

MECP2 belongs to a family of nuclear proteins (including MBD1, MBD2, MBD3 and MBD4) that have a methyl-CpG binding domain. MECP2 is capable of binding specifically to methylated DNA. DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. MECP2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

MECP2
Polyclonal
Unconjugated
Mecp2
1500041B07Rik; AUTSX3; D630021H01Rik; DKFZp686A24160; Mbd5; MECP2; MeCp-2 protein; methyl CpG binding protein 2; methyl-CpG binding protein 2; methyl-CpG-binding protein 2; MRX16; MRX79; MRXS13; MRXSL; PPMX; RS; RTS; RTT; testis tissue sperm-binding protein Li 41a; WBP10
Rabbit
Protein G
RUO
17257, 4204
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Liquid
Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
0.5 mg/mL
PBS with 0.2% gelatin and 0.05% sodium azide
P51608, Q9Z2D6
Mecp2
Synthetic peptides corresponding to residues 11-25 and 181-195 of human MeCP2.
100 μg
Primary
Human, Mouse
Antibody
IgG
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