Invitrogen™ MECR Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA534490

Catalog No. PIPA534490

Description

A suggested positive control is human brain tissue lysate. PA5-34490 can be used with blocking peptide PEP-1532.

The mitochondrial trans-2-enoyl-CoA reductase (MECR), was initially identified as nuclear receptor-binding factor 1 (NRBF1), which can interact with a multitude of nuclear hormone receptors in the presence of the respective ligands. MECR has been shown to be part of the mitochondrial fatty acid synthesis (FAS II) system and to catalyze the NAPDH-dependent reduction of 2-enoyl thioesters, generating saturated acyl-groups. Overexpression of this gene in transgenic mice can lead to cardiac abnormalities, suggesting that inappropriate expression of genes of FAS II can result in the development of hereditary cardiomyopathy.

Specifications

• Antigen: MECR
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Mecr
• Gene Alias: 2-enoyl thioester reductase; AI195831; CGI-63; Enoyl-[acyl-carrier-protein] reductase, mitochondrial; FASN2B; homolog of yeast 2-enoyl thioester reductase; HsNrbf-1; Mecr; mitochondrial 2-enoyl thioester reductase; mitochondrial trans-2-enoyl-CoA reductase; NBRF1; Nrbf1; NRBF-1; nuclear receptor binding factor 1; nuclear receptor-binding factor 1; trans-2-enoyl-CoA reductase, mitochondrial
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 26922, 29470, 51102
• Content And Storage: Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: Q9BV79, Q9DCS3, Q9Z311
• Gene Symbols: Mecr
• Immunogen: A 15 amino acid peptide near the carboxy terminus of human MECR.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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