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MED12 Rabbit anti-Human, Mouse, Polyclonal, Bethyl Laboratories

Rabbit Polyclonal Antibody

Supplier:  Bethyl Laboratories, Inc A300774A

Encompass_Preferred

Catalog No. 50-155-8410


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Description

Description

The recommended shelf life for this product is 1 year from date of receipt. Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections. Based on 100% sequence identity, this antibody is predicted to react with Chimpanzee

The initiation of transcription is controlled in part by a large protein assembly known as the preinitiation complex. A component of this preinitiation complex is a 1.2 MDa protein aggregate called Mediator. This Mediator component binds with a CDK8 subcomplex which contains the protein encoded by this gene, mediator complex subunit 12 (MED12), along with MED13, CDK8 kinase, and cyclin C. The CDK8 subcomplex modulates Mediator-polymerase II interactions and thereby regulates transcription initiation and reinitation rates. The MED12 protein is essential for activating CDK8 kinase. Defects in this gene cause X-linked Opitz-Kaveggia syndrome, also known as FG syndrome, and Lujan-Fryns syndrome. [provided by RefSeq, Aug 2009].
Specifications

Specifications

MED12
Polyclonal
Unconjugated
MED12
Kiaa0192, Mopa, Tnrc11, Trap230
Rabbit
Antigen affinity chromatography
RUO
59024, 9968
4° C
Liquid
Immunohistochemistry, Immunoprecipitation, Western Blot
1 mg/ml
phosphate, tris citrate with 0.09% sodium azide; pH 7-8
A2AGH6, Q93074
MED12
Between 2150 and C-term
100 μL
Primary
Human, Mouse
Antibody
IgG
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