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MEF2C Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
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Catalog No. 501732095 Shop All Proteintech Group Inc Products
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50-173-2095 150 μL
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Catalog No. 50-173-2095 Supplier Proteintech Group Inc Supplier No. 182931AP150UL
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Description

Rabbit Polyclonal Antibody

The immunogen used is a peptide sequence from MEF2C transcript variant 1 that matches transcript variant 5. The antibody can recognize the transcript variant 1, transcript variant 2, and transcript variant 3 of MEF2C.

MEF2C is a transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B cells. May also be involved in neurogenesis and in the development of cortical architecture. Isoform 3 and isoform 4, which lack the repressor domain, are more active than isoform 1 and isoform 2.

Specifications

Antigen MEF2C
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.21 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene MEF2C
Gene Accession No. Q06413, Q8CFN5
Gene Alias myocyte enhancer factor 2C
Gene Symbols Mef2c
Host Species Rabbit
Immunogen Peptide
Purification Method Antigen Affinity Chromatography
Quantity 150 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 17260, 4208, 499497
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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