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Invitrogen™ MEPCE Polyclonal Antibody
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Catalog No. PIPA562438
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PIPA562438 100 μL
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Catalog No. PIPA562438 Supplier Invitrogen™ Supplier No. PA562438
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: AQTPEYDVVL CLSLTKWVHL NWGDEGLKRM FRRIYRHLRP GGILVLEPQP WSSYGKRKTL TETIYKNYYR IQLKPEQFSS YLTSPDVGFS SYELVATPHN TSKGFQRPVY Highest antigen sequence identity to the following orthologs: Mouse - 93%, Rat - 92%.

S-adenosyl-L-methionine-dependent methyltransferase that adds a methylphosphate cap at the 5'-end of 7SK snRNA (7SK RNA), leading to stabilize it (PubMed:17643375, PubMed:19906723, PubMed:30559425). Also has a non-enzymatic function as part of the 7SK RNP complex: the 7SK RNP complex sequesters the positive transcription elongation factor b (P-TEFb) in a large inactive 7SK RNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:17643375). The 7SK RNP complex also promotes snRNA gene transcription by RNA polymerase II via interaction with the little elongation complex (LEC) (PubMed:28254838). In the 7SK RNP complex, MEPCE is required to stabilize 7SK RNA and facilitate the assembly of 7SK RNP complex (PubMed:19906723). MEPCE has a non-enzymatic function in the 7SK RNP complex; interaction with LARP7 within the 7SK RNP complex occluding its catalytic center (PubMed:19906723). [UniProt].
TRUSTED_SUSTAINABILITY

Specifications

Antigen MEPCE
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene mepce
Gene Accession No. Q7L2J0
Gene Alias 7SK snRNA methylphosphate capping enzyme; BCDIN3; Bicoid-interacting protein 3 homolog; bin3 homolog; bin3, bicoid-interacting 3; bin3, bicoid-interacting 3, homolog; Bipl1; D5Wsu46e; fc59f06; FLJ20257; Mepce; methylphosphate capping enzyme; si:ch211-283h6.1; wu:fc59f06; zBCDIN3
Gene Symbols mepce
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human MEPCE. Recombinant protein control fragment (Product #RP-92757).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 56257
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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