MET Mouse anti-Human, Clone: UMAB190, liquid, UltraMAB™

Catalog No.	Quantity
50-168-5290	100 μL

Catalog No. 50-168-5290 Supplier OriGene Supplier No. UM800082

Description

Mouse Monoclonal Antibody

MET is a tyrosine kinase receptor for the hepatocyte growth factor. It is linked to functions such as cell proliferation, scattering, morphogenesis, and survival. Ligand binding at the cell surface induces autophosphorylation of MET that provides docking sites for downstream signaling molecules. After activation of the ligand, MET interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, and STAT3. There interactions lead to the activation of signaling cascades including RAS-ERK, PI3, kinase-AKT, and PLCgamma-PKC. MET plays a role in embryonic development including gastrulation, development of muscles and neurons, angiogenesis, and kidney formation. It also plays a role in adults including wound healing, organ regeneration, and tissue remodeling. MET has been linked to cancers including gastric, renal, and breast; therefore, making it a target for cancer therapeutics and diagnostic testing.

Specifications

• Antigen: MET
• Applications: Immunohistochemistry (Paraffin)
• Classification: Monoclonal
• Clone: UMAB190
• Concentration: 0.5-1.0 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene: MET
• Gene Accession No.: P08581
• Gene Alias: AUTS9, DFNB97, HGFR, RCCP2, c-Met
• Gene Symbols: MET
• Host Species: Mouse
• Immunogen: Human recombit protein fragment corresponding to amino acids 570-885 of human MET produced in E.coli.
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 4233
• Target Species: Human
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1