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Invitrogen™ Metadherin Monoclonal Antibody (2F11C3)
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Catalog No. PIMA515564
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100 μL
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PIMA515564 100 μL
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Catalog No. PIMA515564 Supplier Invitrogen™ Supplier No. MA515564
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Description

Mouse Monoclonal Antibody

MA5-15564 targets Metadherin in indirect ELISA, FACS, IHC, and WB applications and shows reactivity with Human samples. The MA5-15564 immunogen is purified recombinant fragment of human Metadherin expressed in E. Coli. MA5-15564 detects Metadherin which has a predicted molecular weight of approximately 64kDa.

Metadherin (Metastasis adhesion protein), also known as MTDH, LYsine-RIch CEACAM1 co-isolated (LYRIC), is a novel protein that localizes with the tight junction proteins ZO-1 and occludin in polarized epithelial cells. At the tight junction, it acts not as a structural component, but is rather recruited during the maturation of the tight junction complex. Metadherin is overexpressed in breast cancer tissue and breast tumor xenografts, while much lower levels are expressed in normal breast tissue. Metadherin binds to lung vasculature, one of the four common sites of breast cancer metastasis, through a C-terminal segment in the extracellular domain; blocking this lung-homing domain with antibodies or inhibiting metadherin with siRNA has been reported to inhibit breast cancer metastasis.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Metadherin
Applications ELISA, Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Monoclonal
Clone 2F11C3
Concentration Conc. Not Determined
Conjugate Unconjugated
Formulation PBS with 0.03% sodium azide
Gene MTDH
Gene Accession No. Q86UE4
Gene Alias 2610103J23Rik; 3D3; 3D3/Lyric; AEG1; AEG-1; astrocyte elevated gene 1; astrocyte elevated gene-1 protein; AV353288; D8Bwg1112e; LYRIC; LYRIC/ MTDH; LYRIC/3D3; lysine-rich CEACAM1 co-isolated protein; Metadherin; metastasis adhesion protein; MTDH; Protein LYRIC
Gene Symbols MTDH
Host Species Mouse
Immunogen Purified recombinant fragment of human Metadherin expressed in E. Coli.
Purification Method Protein G
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 92140
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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