Invitrogen™ Metallothionein Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA577772

Catalog No. PIPA577772

Description

A 1:1,000 dilution of PA5-77772 was sufficient for detection of Metallothionein in 15 μg of pseudomonas aeruginosa purified Metallothionein (pmtA-GST) protein by ECL immunoblot analysis using goat anti-rabbit IgG:HRP as the secondary antibody. Detects approximately 36 kDa.

This gene is a member of the metallothionein family of genes. Proteins encoded by this gene family are low in molecular weight, are cysteine-rich, lack aromatic residues, and bind divalent heavy metal ions. The conserved cysteine residues co-ordinate metal ions using mercaptide linkages. These proteins act as anti-oxidants, protect against hydroxyl free radicals, are important in homeostatic control of metal in the cell, and play a role in detoxification of heavy metals. Disruption of two metallothionein genes in mouse resulted in defects in protection against heavy metals, oxidative stress, immune reactions, carcinogens, and displayed obesity. MT1A (Metallothionein 1A) is a Protein Coding gene. Diseases associated with MT1A include Menkes Disease and Deficiency Anemia. Among its related pathways are Metal ion SLC transporters and Cellular responses to stimuli. An important paralog of this gene is MT2A.

Specifications

• Antigen: Metallothionein
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: MT1
• Gene Symbols: MT1
• Immunogen: Synthetic peptide from the mid-protein of Pseudomonas aeruginosa Metallothionein.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Bacteria
• Product Type: Antibody
• Isotype: IgG

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.09% sodium azide; pH 7.4
• Gene Alias: Metallothionein; Metallothionein-1
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 20220066
• Content And Storage: -20°C
• Form: Liquid