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Methotrexate, MP Biomedicals™

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Quantity:
10mg
25mg
100mg
500mg
59-05-2
C20H22N8O5
454.447
FBOZXECLQNJBKD-ZDUSSCGKSA-N
methotrexate, abitrexate, rheumatrex, amethopterin, mexate, metatrexan, hdmtx, trexall, methylaminopterinum, antifolan
126941
CHEBI:44185
(2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioic acid
CN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O
59-05-2
C20H22N8O5
454.447
FBOZXECLQNJBKD-ZDUSSCGKSA-N
methotrexate, abitrexate, rheumatrex, amethopterin, mexate, metatrexan, hdmtx, trexall, methylaminopterinum, antifolan
126941
CHEBI:44185
(2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioic acid
CN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O

Acts as a folic acid antagonist. Methotrexate, MP Biomedicals is a mix of 4-amino-10-methylfolic acid and related compounds, structurally similar to folic acid. A potent anticancer agent, it blocks DNA synthesis by blocking production of tetrahydrofolate

Methotrexate is actively transported into cells by the folate transporter. In the cell, it is converted to a high molecular weight polyglutamate metabolite by folypolyglutamate synthase that, in turn, binds to dihydrofolate reductase and inhibits its activity. Methotrexate-polyglutamate is degraded intracellularly by gamma-glutamyl hydrolase.

Methotrexate is an allosteric inhibititor of dihydrofolate reductase (DHFR), the enzyme that catalyzes the conversion of dihydrofolate to tetrahydrofolate. Since tetrahydrolfolate is required for purine and pyrimidine synthesis, methotrexate treatment results in the inhibition of DNA and RNA synthesis.

  • Potent inhibitor of dihydrofolate reductase in DHFR-based protein expression systems
  • Anti-cancer agent used in antitumor studies
  • Effective in treatment of pyrimethamine-resistant Plasmodium vivax malaria parasites
  • Shows immunosuppressive effects, e.g. in rheumatoid arthritis
Melting Point 185°C to 204°C
Boiling Point 184°C to 204°C (monohydrate decomposition)
Quantity 100mg
Solubility Information Soluble in alkaline solutions with decomposition.Insoluble in water, ethanol, chloroform and ether.
Formula Weight 454.4
Optical Rotation 19–24°
Physical Form Orange Powder
Grade USP

Recommended Storage : 4°C