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Cayman Chemical MethysergIdemaleate 5mg
SDP

Supplier:  Cayman Chemical 276585 MG

Encompass_Preferred

A 5-HT1 receptor agonist and 5-HT2 receptor antagonist; binds to recombinant human 5-HT1A (KD = 23.44 nM), 5-HT1E (Ki = 229.09 nM), 5-HT1F (Ki = 33.88 nM), and rodent 5-HT1B receptors (KD = 1,513.56 nM); binds to recombinant human 5-HT2A (Ki = 2.69 nM) and 5-HT2C receptors (KD = 1.26 nM) and is an insurmountable antagonist at 5-HT2B receptors; inhibits 5-HT-induced vasoconstriction in isolated postmortem human basilar arterial spiral strips (pA2 = 8.07); decreases external carotid blood flow in a dose-dependent manner in vagosympathectomized dogs; has antinociceptive activity in mouse models of pain induced by substance P, glutamate, NMDA, AMPA, or kainic acid; reduces zymosan-induced paw edema in rats at 10 mg/kg

Catalog No. 50-294-0906


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