MFN1 Mouse anti-Human, Clone: 3F11C11, Proteintech

Catalog No.	Quantity
50-173-7181	150 μL

Catalog No. 50-173-7181 Supplier Proteintech Group Inc Supplier No. 667761IG150UL

Description

Mouse Monoclonal Antibody

Mitofusin 1 (MFN1) and the related protein MFN2 are mitochondrial membrane GTPase proteins that play a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes. MFN1 and MFN2 form homotypic and heterotypic complexes and coordinately regulate mitochondrial fusion and are essential for embryonic development. When ectopically expressed, MFN1 inhibits the apoptosis-associated amino-terminal conformation change in the apoptotic protein Bax but not its mitochondrial translocation, indicating that MFN1 is involved in the regulating the activation of Bax on the outer mitochondrial membrane.

Specifications

• Antigen: MFN1
• Applications: Immunohistochemistry (Paraffin), Western Blot
• Classification: Monoclonal
• Clone: 3F11C11
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
• Gene: MFN1
• Gene Accession No.: Q8IWA4
• Gene Alias: DKFZp762F247, FLJ20693, Fzo homolog, hfzo1, hfzo2, MFN1, mitofusin 1, Transmembrane GTPase MFN1
• Gene Symbols: MFN1
• Host Species: Mouse
• Immunogen: MFN1 Fusion Protein Ag4890
• Purification Method: Protein A
• Quantity: 150 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 55669
• Target Species: Human
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG2a