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Invitrogen™ MFN2 Monoclonal Antibody (N153/5), PE
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Catalog No. PIMA545672
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100 μg
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PIMA545672 100 μg
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Catalog No. PIMA545672 Supplier Invitrogen™ Supplier No. MA545672
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Description

Mouse Monoclonal Antibody

Rat: 97% identity (226/231 amino acids identical). Human: 92% identity (214/231 amino acids identical) ~55% identity with Mitofusin-1. 1 μg/mL of MA5-45672 was sufficient for detection of Mitofusin-2 in 20 μg of mouse cardiac mitochondrial lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody. Detects approximately 90kDa. No cross-reactivity against Mitofusin-1. This antibody was formerly sold as clone S153-5.

This gene encodes a mitochondrial membrane protein that participates in mitochondrial fusion and contributes to the maintenance and operation of the mitochondrial network. This protein is involved in the regulation of vascular smooth muscle cell proliferation, and it may play a role in the pathophysiology of obesity. Mutations in this gene cause Charcot-Marie-Tooth disease type 2A2, and hereditary motor and sensory neuropathy VI, which are both disorders of the peripheral nervous system. Defects in this gene have also been associated with early-onset stroke. Two transcript variants encoding the same protein have been identified.
TRUSTED_SUSTAINABILITY

Specifications

Antigen MFN2
Applications Immunohistochemistry, Western Blot, Immunocytochemistry
Classification Monoclonal
Clone N153/5
Concentration 1 mg/mL
Conjugate PE
Formulation 2.48mM MES, 95.64mM phosphate with 0.5M EDTA and no preservative; pH 7.4
Gene MFN2
Gene Accession No. O95140, Q80U63, Q8R500
Gene Alias CMT2A; CMT2A2; CPRP 1; CPRP1; D630023P19Rik; Fzo; HMSN6A; HSG; HSG protein; hyperplasia suppressor; hypertension related protein 1; hypertension-related protein; hypertension-related protein 1; Kiaa0214; LOW QUALITY PROTEIN: mitofusin-2; Marf; MFN 2; MFN2; mg:cb01g09; Mitochondrial assembly regulatory factor; mitochondrial transmembrane GTPase FZO1A; mitofusin 2; Mitofusin2; mitofusin-2; si:dkeyp-104h9.2; Transmembrane GTPase MFN2; wu:fb79a11
Gene Symbols MFN2
Host Species Mouse
Immunogen Fusion protein amino acids 370-600 (cytoplasmic N-terminus) of mouse Mitofusin-2.
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 170731, 64476, 9927
Target Species Human, Mouse, Rat
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG2a
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