Invitrogen™ mGluR1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA533812

Catalog No. PIPA533812

Description

Percent identity with other species by BLAST analysis: Human, Chimpanzee, Gorilla, Gibbon, Monkey, Marmoset (100%).

Glutamate is the main excitatory neurotransmitter in the brain. For many years it had been considered to act only on the ligand-gated receptor channels-termed NMDA, AMPA and kainite receptors that are involved in the fast excitatory synaptic transmission. Recently, glutamate has been shown to regulate enzymes producing second messengers via specific receptors coupled to G-proteins. These receptors are called metabotropic glutamate receptors. In expression systems, Group-I receptors stimulate phospholipase C as revealed by an increase in phosphoinositide turnover and calcium release from internal stores. Group-II and -III receptors are coupled to the inhibition of adenylyl cyclase. The Group-I receptors include mGluR1a and mGluR5. The Group-II receptors in include mGluR2 and mGluR3.

Specifications

• Antigen: mGluR1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Grm1
• Gene Alias: 4930455H15Rik; ENSMUSG00000075319; G protein coupled receptor family C group 1 member A; G protein coupled receptor, family C, group 1, member A; G protein-coupled receptor, family C, group 1, member A; glutamate metabotropic receptor 1; glutamate receptor; glutamate receptor, metabotropic 1; Gm10828; GPRC1A; GRM1; GRM1A; Metabotropic glutamate receptor 1; MGLU1; MGLUR1; mGluR1a; nmf373; PPP1R85; protein phosphatase 1, regulatory subunit 85; rcw; SCAR13; wobl
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 2911
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 1 mg/mL
• Formulation: PBS with 0.1% sodium azide
• Gene Accession No.: Q13255
• Gene Symbols: Grm1
• Immunogen: Synthetic 16 amino acid peptide from C-terminus of human GRM1 / MGLUR1.
• Quantity: 50 μg
• Primary or Secondary: Primary
• Target Species: Human, Monkey
• Product Type: Antibody
• Isotype: IgG