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Invitrogen™ MGMT Monoclonal Antibody (MT23.2)
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Catalog No. 357000
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100 μg
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Catalog No. Quantity
35-700-0 100 μg
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Catalog No. 35-700-0 Supplier Invitrogen™ Supplier No. 357000
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Description

Mouse Monoclonal Antibody

MGMT Monoclonal Antibody for Western Blot, IHC, ICC/IF

O6-Methylguanine-DNA Methyltransferase (MGMT) is an important DNA repair protein involved in tumor cell resistance to the cytostatic activity of chemotherapeutic alkylating agents. This protein is also effective in protecting normal cells against the genotoxic and carcinogenic effects of DNA alkylation. The alkylating drug resistance is caused by MGMT's ability to remove DNA alkyl groups introduced in the O6 position of guanine. MGMT is expressed in highly variable amounts, depending upon the cell and tissue type, species, and cellular growth characteristics. In addition, MGMT activity varies among groups of tumors and within a particular type of tumor.
TRUSTED_SUSTAINABILITY

Specifications

Antigen MGMT
Applications Immunohistochemistry, Western Blot, Immunocytochemistry
Classification Monoclonal
Clone MT23.2
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.1% sodium azide; pH 7.4
Gene MGMT
Gene Accession No. P16455
Gene Alias 0-6-methylguanine-DNA methyltransferase; 6-O-methylguanine-DNA methyltransferase; Agat; AGT; AI267024; methylated DNA protein cysteine methyltransferase; methylated-DNA--protein-cysteine methyltransferase; methylguanine-DNA methyltransferase; MGMT; O(6)-alkylguanine-DNA alkyltransferase; O-6-alkylguanine-DNA alkyltransferase; O6-alkylguanine-DNA alkyltransferase; O-6-methylguan; O6-methylguanine-DNA methyltranferase; O-6-methylguanine-DNA methyltransferase; O6-methylguanine-DNA methyltransferase; O-6-methylguanine-DNA-alkyltransferase
Gene Symbols MGMT
Host Species Mouse
Immunogen Recombinant human MGMT.
Purification Method Protein A
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 4255
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG2b
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