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MGMT Rabbit anti-Human, Polyclonal, Proteintech
SDP

Catalog No. 501731437 Shop All Proteintech Group Inc Products
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50-173-1437 150 μL
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Catalog No. 50-173-1437 Supplier Proteintech Group Inc Supplier No. 171951AP150UL
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Description

Rabbit Polyclonal Antibody

O6-Methylguanine-DNA Methyltransferase (MGMT) is an important DNA repair protein involved in tumor cell resistance to the cytostatic activity of chemotherapeutic alkylating agents. This protein is also effective in protecting normal cells against the genotoxic and carcinogenic effects of DNA alkylation. The alkylating drug resistance is caused by MGMT′s ability to remove DNA alkyl groups introduced in the O6 position of guanine. MGMT is expressed in highly variable amounts, depending upon the cell and tissue type, species, and cellular growth characteristics. In addition, MGMT activity varies among groups of tumors and within a particular type of tumor.

Specifications

Antigen MGMT
Applications Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Classification Polyclonal
Concentration 0.34 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene MGMT
Gene Accession No. P16455
Gene Alias MGMT
Gene Symbols MGMT
Host Species Rabbit
Immunogen MGMT Fusion Protein Ag9996
Purification Method Antigen Affinity Chromatography
Quantity 150 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 4255
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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