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Invitrogen™ MICA/B Monoclonal Antibody (6D4), FITC
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Catalog No. PIMA538727
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100 μg
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PIMA538727 100 μg
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Catalog No. PIMA538727 Supplier Invitrogen™ Supplier No. MA538727
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Description

Mouse Monoclonal Antibody

This antibody recognizes a common extracellular epitope on MICA and MICB glycoproteins, transmembrane ligands of CD314 (NKG2D), and is able to block CD314-mediated activation of NK cells and cytotoxic T cells.

MICA encodes the higly polymorphic MHC (HLA) class I chain-related gene A. The protein product is expressed on the cell surface, although unlike canonical class I molecules does not seem to associate with beta-2-microglobulin. It is thought that MICA functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells.
TRUSTED_SUSTAINABILITY

Specifications

Antigen MICA/B
Applications Flow Cytometry
Classification Monoclonal
Clone 6D4
Concentration 1 mg/mL
Conjugate FITC
Formulation PBS with 15mM sodium azide; pH 7.4
Gene MICA
Gene Accession No. Q29980, Q29983
Gene Alias HLA class I antigen; MHC class I chain-related protein A; MHC class I chain-related protein B; MHC class I mic-B antigen; MHC class I polypeptide-related sequence A; MHC class I polypeptide-related sequence B; MHC class I related sequence A; MHC class I-like molecule PERB11.2-IMX; MICA; MIC-A; MICB; MIC-B; PERB11.1; PERB11.2; sMICA; sMICB; soluble MICA; soluble MICB; stress inducible class I homolog; truncated MHC class I polypeptide-related sequence A
Gene Symbols MICA, MICB
Host Species Mouse
Immunogen Transfected C1R cells expressing MICA.
Purification Method Size-exclusion chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 100507436, 4277
Target Species Human
Content And Storage 4°C, store in dark, DO NOT FREEZE!
Product Type Antibody
Form Liquid
Isotype IgG2a
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