Thermo Scientific Chemicals Minocycline hydrochloride, 97%

Description

Minocycline hydrochloride, 97%, CAS # 13614-98-7, is a broad-spectrum compound with antibacterial and anti-inflammatory activities.

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Minocycline hydrochloride is the hydrochloride salt of minocycline, a broad spectrum long-acting derivative of the antibiotic tetracycline, with antibacterial and anti-inflammatory activities

• This compound exerts its action by binding to the bacterial 30S ribosomal subunit and interfering with the binding of tRNA to the ribosomal complex, resulting in the inhibition of protein translation in bacteria

• Minocycline hydrochloride can inhibit the inflammatory enzyme 5-lipoxygenase (5LOX) and may block T cell-microglia interactions. 5LOX catalyzes the synthesis of inflammatory mediators, including prostaglandins and leukotrienes. Therefore, both molecular activities described may contribute to minocycline's neuroprotective activity.

Applications

• This compound is effective against tetracycline-resistant Staphylococcus cultures • Minocycline hydrochloride inhibits lipopolysaccharide mediated inflammatory cytokine tumor necrosis factor (TNF-α) secretion by macrophages

• It inhibits endothelial cell proliferation and angiogenesis in vitro through the translational suppression of HIF-1α

• This compound exhibits anti-tumor activity in glioma by inhibiting membrane type 1 matrix metalloproteinase

Specifications

Chemical Identifiers

• CAS: 13614-98-7
• Molecular Formula: C23H28ClN3O7
• Molecular Weight (g/mol): 493.94
• MDL Number: MFCD00083669
• InChI Key: KDLQIOPKJDNQIM-WUURTAMISA-N
• PubChem CID: 54685925
• IUPAC Name: (4S,4aS,5aR,12aR)-4,7-bis(dimethylamino)-1,10,11,12a-tetrahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide;hydrochloride
• SMILES: [H+].[Cl-].CN(C)[C@H]1[C@@H]2C[C@@H]3CC4=C(C=CC(O)=C4C(O)=C3C(=O)[C@]2(O)C(=O)\C(=C(\N)O)C1=O)N(C)C

• Type: Minocycline Hydrochloride
• Infrared Spectrum: Authentic
• Water: 10% max.
• Quantity: 1 g
• Solubility Information: Solubility in water: slightly soluble. Other solubilities: soluble in dmf and methanol
• Formula Weight: 493.94
• Percent Purity: 97%
• Chemical Name or Material: Minocycline hydrochloride

Safety and Handling

Hazard Category	Warning
Hazard Statement	GHS H Statement Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statement	GHS P Statement Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

SDS

RUO – Research Use Only