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Apexbio Technology LLC IWR-1-endo 1127442-82-3 10mM (in 1mL DMSO)
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Supplier:  Apexbio Technology LLC B23065.1

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IWR-1-endo (CAS 1127442-82-3) is a synthetic small-molecule antagonist of the Wnt/ -catenin signaling pathway It inhibits the activity of WNT1 2 and 3 ligands preventing downstream -catenin accumulation by stabilizing Axin-based degradation complexes and disrupting signaling events mediated via LRP6 and DVL2 Experimentally IWR-1-endo suppresses processes dependent on Wnt/ -catenin activity such as tissue regeneration and epithelial stem cell self-renewal demonstrated notably in zebrafish tailfin regeneration models Additionally it reduces abnormal proliferation induced by APC loss in cancer cell lines highlighting its relevance in oncogenesis research

Catalog No. 50-000-62613


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