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Cayman Chemical ANTIBODY LonIcerIn 1mg
SDP

Supplier:  Cayman Chemical 251481 MG

Encompass_Preferred

A potent and selective inhibitor of GSK3 (IC50s 1.5 and 0.9 for human recombinant GSK3a and GSK2B respectively) has 10-fold selectivity for GSK3 against a panel of 40 kinases at a concentration of 20 M induces time-dependent stabilization ofBcatenin total protein and activates Wnt signaling in vitro has potent antiproliferative activity in BRAF wild-type/NRAS mutant and BRAF mutant melanoma cell lines (IC50s 6.0-11.8 nM) but has limited to no activity in non-melanoma cell lines (IC50s 430 to 20000 nM) knockdown ofBcatenin in A375 and M14 melanoma cells induces LY2090314 resistance in vitro reduces tumor volume in a murine A375 xenograft model as a single agent and synergizes with decabarzine for a greater antitumor effect

Catalog No. 50-293-4932


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