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Thermo Scientific Chemicals Mitomycin C, 5 mg/ml in DMSO, sterile-filtered

Catalog No. AAJ67460XF
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Catalog No. AAJ67460XF Supplier Thermo Scientific Chemicals Supplier No. J67460XF
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Description

Mitomycin C, CAS # 50-07-7, is a methylazirinopyrroloindoledione complex isolated from the bacterium Streptomyces caespitosus and other Streptomyces bacterial species. It is a versatile and potent compound with antibiotic activity and may have potential therapeutic value in the treatment of cancer. | CAS: 50-07-7 | C15H18N4O5 | 334.332 g/mol

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

  • Mitomycin C is a water-soluble, blue-violet crystalline powder, unstable in light and acidic conditions, but maybe stably stored at 2-8°c
  • Bio-reduced mitomycin C generates oxygen radicals, alkylates DNA, and produces inter-strand DNA cross-links, thereby inhibiting DNA synthesis

Applications

  • Mitomycin C is preferentially toxic to hypoxic cells that are resistant to cancer therapy, and is therefore used to study its potential therapeutic effect on advanced stages of cancer
  • At high concentrations, mitomycin C inhibits RNA and protein synthesis and demonstrates strong antibiotic properties towards both Gram-positive and Gram-negative bacteria
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 50-07-7
Molecular Formula C15H18N4O5
Molecular Weight (g/mol) 334.332
MDL Number MFCD00078109
InChI Key NWIBSHFKIJFRCO-WUDYKRTCSA-N
PubChem CID 5746
ChEBI CHEBI:27504
SMILES CC1=C(C(=O)C2=C(C1=O)N3CC4C(C3(C2COC(=O)N)OC)N4)N

Specifications

Type Mitomycin C
Physical Form Liquid
Quantity 1 mL
UN Number UN1987
Chemical Name or Material Mitomycin C, 5mg/mL in ethanol, sterile-filtered

Safety and Handling

Hazard Category Danger
Hazard Statement GHS H Statement
H225-H371
Highly flammable liquid and vapor.
May cause damage to organs.
Precautionary Statement GHS P Statement
P210-P260-P280-P303+P361+P353-P405-P501a
Keep away from heat/sparks/open flames/hot surfaces.
- No smoking.
Do not breathe dust/fume/gas/mist/vapors/spray.
Wear protective gloves/protective clothing/eye protection/face protection.
IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing.
Rinse skin with water/shower.
Store locked up.
Dispose of contents/container in accordance with local/regional/national/international regulations.
DOTInformation Transport Hazard Class: 3; Packaging Group: III; Proper Shipping Name: ALCOHOLS, N.O.S.
EINECSNumber 200-008-6
RTECSNumber CN0700000
TSCA Yes
storageNote1 -30° to -10°C
Recommended Storage Store at -20°C
SDS

RUO – Research Use Only

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