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Mitoxantrone dihydrochloride, Tocris Bioscience™

Catalog No. 425050
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50 mg
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Catalog No. Quantity
42-505-0 50 mg
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Catalog No. 42-505-0 Supplier R&D Systems Supplier No. 4250/50
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Description

Topoisomerase II inhibitor; immunosuppressive and antineoplastic agent

Type II DNA topoisomerase inhibitor. Disrupts DNA synthesis and repair and induces damage by DNA cross-linking. Also inhibits PIM1 kinase (IC50 = 51 nM). Immunomodulatory, antineoplastic and chemotherapeutic agent. Also USP11 inhibitor (IC50= 3.15 μM). Induces cell death of pancreatic cancer cell lines expressing wild-type BRCA2.

Chemical Identifiers

CAS 70476-82-3
Molecular Formula C22H30Cl2N4O6
Molecular Weight (g/mol) 517.404
InChI Key ZAHQPTJLOCWVPG-UHFFFAOYSA-N
Synonym mitoxantrone hydrochloride, mitoxantrone dihydrochloride, mitoxantrone hcl, novantrone, novantron, immunex, bisantrone, unii-u6usw86rd0, dhad
PubChem CID 51082
ChEBI CHEBI:50727
IUPAC Name 1,4-dihydroxy-5,8-bis[2-(2-hydroxyethylamino)ethylamino]anthracene-9,10-dione;dihydrochloride
SMILES C1=CC(=C2C(=C1NCCNCCO)C(=O)C3=C(C=CC(=C3C2=O)O)O)NCCNCCO.Cl.Cl

Specifications

Quantity 50 mg
Formula Weight 517.4
Percent Purity >98%
Chemical Name or Material Mitoxantrone dihydrochloride

Safety and Handling

Recommended Storage Desiccate at Room Temperature
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