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Apexbio Technology LLC MJ33 (lithium salt)(Synonyms: MJ33 lithium salt, MJ33 Li salt, MJ33 inhibitor), 25mg, CAS: 1007476-63-2;199106-13-3.
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Supplier:  Apexbio Technology LLC C534625

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MJ33 (lithium salt CAS 1007476-63-2 199106-13-3) is a small molecule inhibitor of the acidic calcium-independent phospholipase A2 (aiPLA2) activity of peroxiredoxin-6 (Prdx6) Prdx6 exhibits dual enzymatic functions encompassing both glutathione peroxidase and PLA2 activities It plays a role in lung surfactant lipid metabolism particularly processing dipalmitoylphosphatidylcholine MJ33 selectively suppresses aiPLA2 activity as demonstrated through inhibition of phosphorylation-stimulated recombinant and native Prdx6 in vitro Moreover MJ33 has shown protective effects in animal models attenuating ROS generation inflammatory cytokine release NF- B activation and tissue damage in LPS-induced acute lung injury highlighting its utility for inflammation-related biomedical research

Catalog No. 50-000-61347


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