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Invitrogen™ MKP-1 Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA585131
Description
Keep as concentrated solution. Predicted reactivity: Mouse (98%), Rat (98%), Zebrafish (92%), Xenopus laevis (95%), Pig (100%), Chicken (97%), Rhesus Monkey (100%), Bovine (100%). Positive Control: mouse liver. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues. Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes. Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation.
Specifications
MKP-1 | |
Polyclonal | |
Unconjugated | |
Dusp1 | |
3ch134; 3CH134/CL100 PTPase; CL 100; CL100; dual specificity phosphatase 1; dual specificity protein phosphatase 1; Dual specificity protein phosphatase hVH1; DUS1; DUSP1; EC 3.1.3.16; EC 3.1.3.48; erp; HVH1; MAP kinase phosphatase 1; MAP kinase phosphatase-1; mitogen-activated protein (MAP) kinase phosphatase-1; mitogen-activated protein kinase phosphatase 1; mitogen-activated protein kinase phosphatase-1; MKP1; mkp-1; oxidative stress-inducible protein tyrosine phosphatase; protein tyrosine phosphatase non-receptor type 16; protein tyrosine phosphatase, non-receptor type 16; protein-tyrosine phosphatase 3CH134; Protein-tyrosine phosphatase CL100; protein-tyrosine phosphatase ERP; Protein-tyrosine phosphatase non-receptor type 16; PTPN10; Ptpn16; serine/threonine specific protein phosphatase; U19515; VH1 | |
Rabbit | |
Antigen Affinity Chromatography | |
RUO | |
1843, 19252 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
Western Blot | |
0.2 mg/mL | |
PBS with 10% glycerol and 0.01% thimerosal; pH 7 | |
P28562, P28563 | |
Dusp1 | |
Recombinant protein encompassing a sequence within the center region of human DUSP1. | |
100 μL | |
Primary | |
Human, Mouse | |
Antibody | |
IgG |
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