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ML 228, R&D Systems™
SDP

Catalog No. 456510
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10 mg
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Catalog No. Quantity
45-651-0 10 mg
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Catalog No. 45-651-0 Supplier R&D Systems Supplier No. 4565/10

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Description

A Tocris product, part of R&D Systems. HIF pathway activator

HIF pathway activator (EC50 values are 1.23 and 1.4 μM for HRE gene reporter assay and HIF-1α nuclear translocation assay respectively); acts via chelation of iron, independently of PHD. Also exhibits > 80% inhibition of the human A3 receptor, dopamine transporter, μ receptor, hERG and 5-HT2B receptor, and rat sodium channel site 2, at a concentration of 10 μM.

Chemical Identifiers

CAS 1357171-62-0
Molecular Formula C27H21N5
Molecular Weight (g/mol) 415.5
InChI Key QNRODODTMXCRKU-UHFFFAOYSA-N
Synonym n-1,1'-biphenyl-4-ylmethyl-6-phenyl-3-pyridin-2-yl-1,2,4-triazin-5-amine, ml228 probe, 6-phenyl-n-4-phenylphenyl methyl-3-2-pyridinyl-1,2,4-triazin-5-amine, n-1,1'biphenyl-4-ylmethyl-6-phenyl-3-2-pyridinyl-1,2,4-triazin-5-amine, n-biphenyl-4-ylmethyl-6-phenyl-3-pyridin-2-yl-1,2,4-triazin-5-amine
PubChem CID 46742353
IUPAC Name 6-phenyl-N-[(4-phenylphenyl)methyl]-3-pyridin-2-yl-1,2,4-triazin-5-amine
SMILES C1=CC=C(C=C1)C2=CC=C(C=C2)CNC3=C(N=NC(=N3)C4=CC=CC=N4)C5=CC=CC=C5

Specifications

Quantity 10 mg
Formula Weight 415.49
Percent Purity >98%
Product Line Tocris
Chemical Name or Material ML 228

Safety and Handling

Recommended Storage Store at -20°C
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